![]() Further, we investigated the biological role of the identified AF-associated loci by leveraging gene expression and epigenomic datasets. Here we sought to explore the genetic architecture of AF in a non-European population and improve the statistical power of AF-GWASs by performing a large-scale Japanese GWAS, followed by a cross-ancestry meta-analysis. However, because the vast majority of AF-GWASs have been predominantly performed in European populations, the genetic pathophysiology of AF in non-European populations is not comprehensively understood, and it is difficult to apply polygenic risk scores (PRSs) derived from such GWASs to non-European populations. Recent genome-wide association studies (GWASs) have identified more than 100 AF-associated loci, some of which are involved in cardiac developmental, electrophysiological, contractile and structural pathways 5, 6, 7, 8. Besides conventional clinical risk factors such as aging, obesity, hypertension and heart failure, the genetic contribution to the development of AF is also widely recognized. Despite progress in diagnostic and therapeutic technologies, a substantial number of patients with AF are admitted with life-threatening complications such as stroke and heart failure 3, causing a considerable burden on patients and public healthcare systems 4. The global prevalence of AF is increasing due to the rapid aging of the general population and intensified search for subclinical AF 2. Our results provide new biological and clinical insights into AF genetics and suggest their potential for clinical applications.Ītrial fibrillation (AF) is the most common cardiac arrhythmia, affecting approximately 46.3 million individuals worldwide 1. A polygenic risk score derived from the cross-ancestry meta-analysis predicted increased risks of cardiovascular and stroke mortalities and segregated individuals with cardioembolic stroke in undiagnosed AF patients. Integrative analysis with ChIP-seq data and functional assessment using human induced pluripotent stem cell-derived cardiomyocytes demonstrated ERRg as having a key role in the transcriptional regulation of AF-associated genes. Transcriptome-wide association analysis identified IL6R as a putative causal gene, suggesting the involvement of immune responses. A cross-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 new susceptibility loci. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Nature Genetics volume 55, pages 187–197 ( 2023) Cite this articleĪtrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. ![]() There are also sections on books and arts.Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction Towards the front of each issue are editorials, news and feature articles on issues of general interest to scientists, including current affairs, science funding, business, scientific ethics and research breakthroughs. ![]() Research scientists are the primary audience for the journal, but summaries and accompanying articles are intended to make many of the most important papers understandable to scientists in other fields and the educated general public. There are many fields of scientific research in which important new advances and original research are published as either articles or letters in Nature. Most scientific journals are now highly specialized, and Nature is among the few journals (the other weekly journals Science and Proceedings of the National Academy of Sciences are also prominent examples) that still publish original research articles across a wide range of scientific fields. Nature, first published on 4 November 1869, is ranked the world s most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |